|Although numerous therapies are available for the treatment of moderate to severe ulcerative colitis (UC), many patients still suffer poor quality of life and outcomes. Ulcerative colitis is a relapsing and remitting disease, with varied and changing incidence rates worldwide. It also has an unpredictable disease course and is associated with a high health economic burden. These and other findings underscore the importance of learning about new therapies that may reduce the treatment burden of UC care. The therapeutic landscape is continuing to evolve, and agents that target the immunological pathways of UC are of great interest to gastroenterologists and other health care professionals. This Game On! activity is an interactive quiz of knowledge and confidence in which participants answer questions, then select the level of confidence in their answers to achieve the highest score among their peers. The faculty of this program will explore investigational agents with unique mechanisms of action in late-stage development for the treatment of patients with moderate to severe UC as well as apply new clinical data on the efficacy and safety of therapeutic agents that target the immunological pathways of UC. Patient-reported outcomes measures that may improve the treatment of inflammatory bowel disease will also be examined in the game.