Rare Diseases Update: Genetics and Targeted Treatment in HAE and CVID

0.50 ANCC
$0 FEE
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infectious disease

Activity Release Date:  January 5, 2021
Activity Expiration Date:  January 4, 2022


Provider Statement

This activity is jointly provided by AKH Inc., Advancing Knowledge in Healthcare and RMEI Medical Education, LLC.

Advancing Knowledge in Healthcare RMEI

Support Statement

This activity is supported by independent educational grants from Takeda Pharmaceuticals U.S.A., Inc., Pharming Healthcare, Inc., BioCryst Pharmaceutical, Inc., and Grifols. 

Target Audience

This educational activity is designed for allergy/immunology clinicians, including physicians, nurse practitioners, physician assistants, and nurses who manage patients with hereditary angioedema (HAE) and/or common variable immune deficiency (CVID).   

Activity Description

This activity, presented by Dr. Marc A. Riedl, highlights recently updated HAE clinical practice guidelines, treatment advances, and emerging therapies for HAE. Dr. Riedl discusses how to distinguish CVID from other immunodeficiencies as well as immunoglobulin replacement therapy and emerging targeted therapies for CVID. Learners will gain insight on optimizing individualized patient care and considerations for improving quality of life for patients with HAE and CVID.

Learning Objectives

After engaging in this activity, clinicians will be able to:  

  • Recognize the role of genetic and new diagnostic testing in the evaluation of patients with hereditary angioedema (HAE)
  • Evaluate the efficacy and safety of treatments that are indicated and under investigation for HAE
  • Identify appropriate genetic testing strategies for common variable immune deficiency (CVID) that may change management strategies
  • Describe the IgRT options indicated for the treatment of CVID 


Marc A. Riedl, MD, MS 
Professor of Medicine 
Clinical Director
, US HAEA Angioedema Center 
Clinical Service Chief & Training Program Director 
Division of Rheumatology, Allergy & Immunology 
University of California, San Diego 
San Diego, CA  


Advancing Knowledge in Healthcare RMEI

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of AKH Inc., Advancing Knowledge in Healthcare and RMEI Medical Education, LLC. AKH Inc., Advancing Knowledge in Healthcare is accredited by the ACCME to provide continuing medical education for physicians.

AKH Inc., Advancing Knowledge in Healthcare designates this enduring activity for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.  

Physician Assistants  
NCCPA accepts AMA PRA Category 1 Credit(s)™ from organizations accredited by ACCME.  

abimSuccessful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.5 medical knowledge MOC points and 0 patient safety MOC credit in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.  

AKH, Inc., Advancing Knowledge in Healthcare is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

This activity is awarded 0.5 contact hour(s).

This activity is jointly provided by AKH Inc., Advancing Knowledge in Healthcare and RMEI Medical Education, LLC.  

Criteria For Success

Statements of credit will be awarded based on the participant’s attendance, participation in the pre-/post-test, and submission of the activity evaluation form. A statement of credit will be available upon completion of an evaluation/claimed credit form. If you have questions about this CME activity, please contact AKH Inc. at tbrignoni@akhcme.com.

Credit Designation

0.5 AMA PRA Category 1 Credit(s)TM

0.5 ANCC contact hour(s)

How to Participate in this Activity and Obtain CME Credit 

To claim credit and print your CME/CE certificate, you must complete the post-test, evaluation, and request for credit, following your participation in the activity. You will have the ability to print your CME/CE certificate. A statement of credit will be issued only upon completion of the program evaluation. 

PHYSICIANS: An important note about ABIM MOC Part II points. Successful completion of this activity enables eligible participants to earn up to 0.5 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Upon completion of claiming CME credit, you will receive an e-mail for claiming MOC points. By following the instructions in the e-mail, your MOC points will be sent to your account within 30 days. 

If you have questions regarding your certificate, please contact AKH, Inc. via e-mail at tbrignoni@akhcme.com.

Your Feedback is Important!

*The expense for this gift card is solely funded by RMEI Medical Education, LLC.
No supporter funding was used for the expense of this gift card.

Rules and Regulations 
This sweepstakes is managed by RMEI Medical Education, LLC (RMEI), a full-service medical education company. The winner will be selected via automated random drawing on a quarterly basis from among all eligible entries and notified through the contact information provided. In accordance with our privacy policy, we do not share your information with any third parties. By entering the sweepstakes, you grant RMEI permission to use your e-mail address to reach you for notification and prize fulfillment. Only individuals who complete the evaluation forms and provide contact information will be eligible to win. Open to those who have a US postal address and who are 18 years or older. Only one prize per person and per household will be awarded. The prize will be a $100 Amazon gift card.


Marc A. Riedl, MD, MS, has affiliations with Adverum, Attune, BioCryst, BioMarin, CSL Behring, Ionis, Kalvista, Pfizer, Pharming, Pharvaris, RegenexBio, Shire/Takeda (Consultant); BioCryst, CSL Behring, Ionis, Shire/Takeda (Contracted Research); CSL Behring, Grifols, Pharming, Shire/Takeda (Speakers Bureau).

Jennifer Logan, MD, MPH, Medical Writer,
has disclosed no financial relationships.  
Sherri Kramer, MD, RMEI Medical Director, has disclosed no financial relationships.  
Dorothy Caputo, MA, BSN, RN, AKH Director of Accreditation, Planner, has nothing to disclose.
Patricia Brignoni, AKH Director of Operations/Reviewer, has disclosed no financial relationships.  
AKH Inc. and RMEI planners and reviewers, have disclosed no financial relationships.  

Disclosure Declarations

It is the policy of AKH Inc. and RMEI Medical Education, LLC to ensure independence, balance, objectivity, scientific rigor, and integrity in all of its continuing education activities. The faculty must disclose to the participants any significant relationships with commercial interests whose products or devices may be mentioned in the activity or with the commercial supporter of this continuing education activity. Identified conflicts of interest are resolved by AKH prior to accreditation of the activity and may include any of, or combination of, the following: attestation to non-commercial content; notification of independent and certified CME expectations; referral to National Faculty Initiative training; restriction of topic area or content; restriction to discussion of science only; amendment of content to eliminate discussion of device or technique; use of other faculty for discussion of recommendations; independent review against criteria ensuring evidence support recommendation; moderator review; and peer review.

Disclosure of Unlabeled Use and Investigational Product   

This educational activity may include discussion of uses of agents that are investigational and/or unapproved by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.  


This course is designed solely to provide the healthcare professional with information to assist in his/her practice and professional development and is not to be considered a diagnostic tool to replace professional advice or treatment. The course serves as a general guide to the healthcare professional, and therefore, cannot be considered as giving legal, nursing, medical, or other professional advice in specific cases. AKH Inc. and RMEI Medical Education, LLC specifically disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through participant's misunderstanding of the content.  

Copyright Statement


CME Questions?

If you have questions about this CME activity, please contact AKH Inc. at tbrignoni@akhcme.com.