Neuromyelitis Optica Spectrum Disorder: Improving Diagnosis and Treatment

1.00 CME
1.00 ABO MOC
$0 FEE


Provider Statement

This continuing medical education activity is provided by Vindico Medical Education

Support Statement

This activity is supported by an educational grant from Genentech, Inc.

Activity Description

Neuromyelitis optica spectrum disorder (NMOSD) is characterized by inflammation in the optic nerve and spinal cord. Diagnostic criteria of NMOSD have evolved and are now based on the presence of core clinical characteristics, NMO-specific aquaporin-4 antibody status, and magnetic resonance imaging—which allows for a differential diagnosis. Until recently, treatment options for NMOSD have been limited, but there are now 3 US Food and Drug Administration–approved therapies for the treatment of NMOSD, and others under clinical evaluation. These approved and emerging therapy options have changed the treatment landscape for NMOSD by reducing the number of NMOSD relapses and enhancing clinical outcomes for these patients. Within this CME activity, experts in the field will review the pathophysiology of NMOSD and its burden in patients, summarize evidence-based diagnostic criteria and best practices for the differential diagnosis of NMOSD, as well as assess the efficacy of recently approved and emerging therapies for the treatment and prevention of NMOSD relapses.

Target Audience

The intended audience for this activity is ophthalmologists, optometrists, and other health care professionals involved in the management of patients with NMOSD.

Learning Objectives

Upon successful completion of this educational activity, participants should be better able to:

  • Review the pathophysiology of NMOSD and its burden in patients.
  • Summarize evidence-based diagnostic criteria and best practices that assist in the differential diagnosis of NMOSD.
  • Assess the efficacy of conventional and emerging therapies for the treatment and prevention of NMOSD attacks.

Activity Chair

Andrew G. Lee, MD
Chairman of Ophthalmology
Blanton Eye Institute
Houston Methodist Hospital
Clinical Professor of Ophthalmology
University of Texas Medical Branch MD Anderson Cancer Center
Adjunct Professor of Ophthalmology
Baylor College of Medicine
Houston, TX
Professor of Ophthalmology, Neurology, and Neurosurgery
Weill Cornell Medical College
New York, NY
Clinical Professor of Ophthalmology
University of Buffalo, SUNY
Buffalo, NY
Adjunct Professor of Ophthalmology
University of Iowa
Iowa City, IA


Heather E. Moss, MD, PhD
Associate Professor of Ophthalmology
Stanford University
Palo Alto, CA

Prem S. Subramanian, MD, PhD
Professor of Ophthalmology, Neurology, and Neurosurgery
University of Colorado School of Medicine
Vice Chair for Academic Affairs
Division Head, Neuro-Ophthalmology
UCHealth Sue Anschutz-Rodgers Eye Center
Aurora, CO


Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP


Vindico Medical Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation

Vindico Medical Education designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

ABOSuccessful completion of this CME activity, which includes participation in the evaluation component, enables the learner to satisfy the Lifelong Learning requirements for the American Board of Ophthalmology’s Maintenance of Certification (ABO MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting MOC credit.

Upon successful completion, learners who opt-in by providing their ABO ID and DOB (MM/DD) will earn MOC credits equivalent to the amount of CME credits claimed for the activity.

This enduring material is approved for 1 year from the date of original release, January 14, 2021 to January 13, 2022.

How to Participate in This Activity and Obtain CME Credit

To participate in this CME activity, you must read the objectives, answer the polling and pretest questions, view the content, and complete the posttest and evaluation. Provide only one (1) correct answer for each question. A satisfactory score is defined as answering 2 of the 3 posttest questions correctly. Upon receipt of the completed materials, if a satisfactory score on the posttest is achieved, Vindico Medical Education will issue an AMA PRA Category 1 Credit(s)™ certificate.


In accordance with the Accreditation Council for Continuing Medical Education’s Standards for Commercial Support, all accredited providers are required to mitigate and disclose to the activity audience the relevant financial relationships of the planners, teachers, and authors involved in the development of accredited content. An individual has a relevant financial relationship if he or she has a financial relationship in any amount occurring in the past 12 months with a commercial interest whose products or services are discussed in the accredited activity content over which the individual has control. Relationship information appears below.  

Activity Chair and Faculty report the following relationship(s)

Andrew G. Lee, MD
No relevant financial relationships to disclose.

Heather E. Moss, MD, PhD
Consulting Fee: Legal firms, Verily
Honoraria: AAN, Elsevier, Ology Medical Education, Springer, Wolters Kluwer
Grants: Myelin Repair Foundation, NANOS, NIH, Research to Prevent Blindness, Stanford
Advisory Board: Genentech

Prem S. Subramanian, MD, PhD
Consulting Fee: GenSight Biologics, Horizon Therapeutics, Invex Therapeutics
Contracted Research: GenSight Biologics, Santhera

Reviewer reports the following relationship(s)

Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP
No relevant financial relationships to disclose. 

Vindico Medical Education staff report the following relationship(s)

No relevant financial relationships to disclose.

Signed disclosures are on file at Vindico Medical Education, Office of Medical Affairs and Compliance.

Unlabeled and Investigational Usage

The audience is advised that this continuing medical education activity may contain references to unlabeled uses of US Food and Drug Administration (FDA)–approved products or to products not approved by the FDA for use in the United States. The faculty members have been made aware of their obligation to disclose such usage. All activity participants will be informed if any speakers/authors intend to discuss either non–FDA-approved or investigational use of products/devices.

Copyright Statement

Created and published by Vindico Medical Education, 6900 Grove Road, Building 100, Thorofare, NJ 08086-9447. Telephone: 856-994-9400; Fax: 856-384-6680. Printed in the USA. Copyright © 2021 Vindico Medical Education. All rights reserved. No part of this publication may be reproduced without written permission from the publisher. The material presented at or in any of Vindico Medical Education continuing medical education activities does not necessarily reflect the views and opinions of Vindico Medical Education. Neither Vindico Medical Education nor the faculty endorse or recommend any techniques, commercial products, or manufacturers. The faculty/authors may discuss the use of materials and/or products that have not yet been approved by the US Food and Drug Administration. All readers and continuing education participants should verify all information before treating patients or utilizing any product.

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