Early Childhood Exposures and Risk for Adult Disease: November 2015
Keck School of Medicine of USC and Pediatric Annals
Table of Contents
The Perinatal Origins of Cardiovascular Disease
Alison Chu, MD; and Theodore De Beritto, MD, MS
Neurodevelopmental Implications of Neonatal Pain and Morphine Exposure
Kalpashri Kesavan, MBBS
Early-Life Exposure to Antibiotics, Alterations in the Intestinal Microbiome, and Risk of Metabolic Disease in Children and Adults
Sushmita G. Yallapragada, MD; Colleen B. Nash, MD; and Daniel T. Robinson, MD
Childhood Exposures and Risk of Malignancy in Adulthood
Vivian Y. Chang, MD, MS; and Tom B. Davidson, MD
Support Statement: There is no commercial support for this activity.
1. Explain the impact of maternal nutrition, placental insufficiency, and glucocorticoids on the development and genetic programming of a fetus.
2. Recognize the harmful effects of untreated neonatal pain and the importance of optimal pain management.
3. Recognize that perturbation of the intestinal microbiome by antibiotics may lead to metabolic consequences later in life.
4. Identify relative risk factors and associations between childhood exposures and adultonset malignancy.
Faculty names and affiliations: See Table of Contents
Reviewer names: Thomas J. Selva, MD, CME Director, Pediatric Annals; Stanford T. Shulman, Editor-in-chief, Pediatric Annals
Guest Editor: Alison Chu, MD
Disclosure statement: In accordance with the Accreditation Council for Continuing Medical Education’s Standards for Commercial Support, all CME providers are required to disclose to the activity audience the relevant financial relationships of the planners, teachers, and authors involved in the development of CME content. An individual has a relevant financial relationship if he or she has a financial relationship in any amount occurring in the last 12 months with a commercial interest whose products or services are discussed in the CME activity content over which the individual has control. Relationship information appears at the beginning of each CME-accredited article in this issue and also on this page.
Faculty members report the following financial relationships:
Thomas J. Selva, MD, has disclosed no relevant financial relationships.
Stanford T. Shulman, MD, has disclosed no relevant financial relationships.
Authors report the following financial relationships: Alison Chu has no relevant financial relationships to disclose. Theodore De Beritto has no relevant financial relationships to disclose. Kalpashri Kesavan has no relevant financial relationships to disclose. Sushmita G. Yallapragada has no relevant financial relationships to disclose. Colleen B. Nash has no relevant financial relationships to disclose. Daniel T. Robinson has no relevant financial relationships to disclose. Vivian Y. Chang has no relevant financial relationships to disclose. Tom B. Davidson has no relevant financial relationships to disclose..
The staff of Keck School of Medicine of USC and Pediatric Annals have disclosed no relevant financial relationships.
Signed disclosures are on file at Keck School of Medicine of USC.
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Keck School of Medicine of USC and SLACK Incorporated. The Keck School of Medicine of USC is accredited by the ACCME to provide continuing medical education for physicians.
Credit designation: The Keck School of Medicine of USC designates this enduring material for a maximum of 3 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Release date: November 1, 2015.
Expiration Date: November 30, 2018.
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