Major Depressive Disorder: Achieving Adequate Treatment Response and Patient-related Goals in Primary Care – A Game On! Challenge

0.75 CME
0.75 AAFP
$0 FEE
Major Depressive Disorder: Achieving Adequate Treatment Response and Patient-related Goals in Primary Care – A Game On! Challenge


Provider Statement

This continuing medical education activity is provided by Vindico Medical Education.

Support Statement

Supported by an educational grant from Takeda Pharmaceuticals U.S.A., Inc. and Lundbeck.

Target Audience

The intended audience for this activity is family physicians, psychiatrists, and other health care professionals involved in the management of patients with major depressive disorder (MDD).

Learning Objectives

Upon completion of this educational activity, the participant may be better able to:

  • Identify inadequate responses to antidepressant therapy that should prompt consideration of switching therapy.
  • Incorporate shared decision-making to engage and involve the patient when considering switching antidepressants.
  • Incorporate alternative treatment strategies when patients have an inadequate response to initial antidepressant therapy.
  • Incorporate psychotherapeutic approaches into the overall management of patients with MDD

Activity Chair

Michael E. Thase, MD
Professor of Psychiatry
Perelman School of Medicine
University of Pennsylvania
Philadelphia, PA


Leslie Citrome, MD, MPH
Clinical Professor of Psychiatry and Behavioral Sciences
New York Medical College
Valhalla, NY

Anita H. Clayton, MD
David C. Wilson Professor and Chair
Department of Psychiatry and Neurobehavioral Sciences
University of Virginia School of Medicine
Charlottesville, VA

Larry Culpepper, MD, MPH, FAAFP
Professor of Family Medicine
Boston University School of Medicine
Boston, MA


Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP


Vindico Medical Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation

Vindico Medical Education designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This enduring material is approved for 1 year from the date of original release, November 19, 2019, through November 18, 2020.

This Enduring Material activity, Major Depressive Disorder: Achieving Adequate Treatment Response and Patient-related Goals in Primary Care – A Game On! Challenge, has been reviewed and is acceptable for up to 0.75 Prescribed credit(s) by the American Academy of Family Physicians. AAFP certification begins 11/30/2019. Term of approval is for one year from this date. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

AMA/AAFP Equivalency: AAFP Prescribed Credit is accepted by the American Medical Association as equivalent to AMA PRA Category 1 Credit(s)™ toward the AMA Physician’s Recognition Award. When applying for the AMA PRA, Prescribed credit earned must be reported as Prescribed, not as Category 1.

How to Participate in this Activity and Obtain CME Credit

To participate in this CME activity, you must read the objectives, answer the pretest questions, view the content, and complete the posttest and evaluation. Provide only one (1) correct answer for each question. A satisfactory score is defined as answering 3 of the 4 posttest questions correctly. Upon receipt of the completed materials, if a satisfactory score on the posttest is achieved, Vindico Medical Education will issue a Prescribed Credits or AMA PRA Category 1 Credit(s)™ Certificate.

MIPS Qualifying Activity:
Completion of this accredited CME activity meets the expectations of an Accredited Safety or Quality Improvement Program (IA_PSPA_28) for the Merit-based Incentive Payment Program (MIPS). Participants who successfully complete the activity and its performance assessment will receive printable documentation of successful completion for MIPS self-reporting.
To meet the criteria for improvement activities in the Merit-Based Incentive Payment System (MIPS) of QPP, accredited CME providers need to implement activities that:

  • address a quality or safety gap that is supported by a needs assessment or problem analysis, or support the completion of such a needs assessment as part of the activity;
  • have specific, measurable aim(s) for improvement;
  • include interventions intended to result in improvement;
  • include data collection and analysis of performance data to assess the impact of the interventions; and
  • define meaningful clinician participation in their activity, describe the mechanism for identifying clinicians who meet the requirements, and provide participant completion information.


In accordance with the Accreditation Council for Continuing Medical Education’s Standards for Commercial Support, all CME providers are required to disclose to the activity audience the relevant financial relationships of the planners, teachers, and authors involved in the development of CME content. An individual has a relevant financial relationship if he or she has a financial relationship in any amount occurring in the last 12 months with a commercial interest whose products or services are discussed in the CME activity content over which the individual has control. Relationship information appears below.

Activity Chair and Faculty report the following relationship(s)

Leslie Citrome, MD, MPH
Royalty Details: UpToDate, Wiley
Consulting Fee: Acadia, Alkermes, Allergan, Indivior, Intra-Cellular Therapeutics, Janssen, Lundbeck, Merck, Neurocrine Biosciences, Noven, Osmotica, Otsuka, Pfizer, Shire, Sunovion, Takeda, Teva, Vanda
Speakers Bureau: Acadia, Alkermes, Allergan, Janssen, Lundbeck, Merck, Neurocrine Biosciences, Otsuka, Pfizer, Shire, Sunovion, Takeda, Teva
Ownership Interest: Bristol-Myers Squibb, Eli Lilly, Johnson & Johnson, Merck, Pfizer

Anita H. Clayton, MD
Royalty Details: Guilford Publications
Intellectual Property/Patents: Changes in Sexual Functioning Questionnaire
Consulting Fee: Acadia, Alkermes, Allergan, AMAG Pharmaceuticals, Fabre-Kramer, Lundbeck, Palatin Technologies, S1 Biopharma, Sage Therapeutics, Sprout Pharmaceuticals, Takeda
Contracted Research: Endoceutics, Janssen, Sage Therapeutics, Takeda
Ownership Interest: Euthymics, S1 Biopharma

Larry Culpepper, MD, MPH, FAAFP
Royalty Details: UpToDate
Consulting Fee: Alkermes, Harmony Biosciences, Jazz Pharmaceuticals, Merck, Shire PLC, Sunovion, Supernus 
Ownership Interest: M3 Information 
Other Disclosures: Payment from Physicians Postgraduate Press as Editor in Chief of the Primary Care Companion for CNS Diseases

Michael E. Thase, MD
Salary Details: (Spouse): 
Peleton Advantage 
Royalty Details: 
American Psychiatric Foundation, Guilford Publications, Herald House, W.W. Norton & Company 
Consulting Fee: 
Acadia, Akili, Alkermes PLC, Allergan, Cerecor, Fabre-Kramer Pharmaceuticals, Gerson Lehrman Group, Guidepoint, H. Lundbeck A/S, Johnson & Johnson, moksha8, Nestle, Neuralstem, Novartis, Otsuka, Pfizer, Sage Pharmaceuticals, Sunovion

Reviewer reports the following relationship(s)

Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP
No relevant financial relationships to disclose.

Vindico Medical Education staff report the following relationship(s)

No relevant financial relationships to disclose.

Signed disclosures are on file at Vindico Medical Education, Office of Medical Affairs and Compliance.

Unlabeled and Investigational Usage

The audience is advised that this continuing medical education activity may contain references to unlabeled uses of US Food and Drug Administration (FDA)-approved products or to products not approved by the FDA for use in the United States. The faculty members have been made aware of their obligation to disclose such usage. All activity participants will be informed if any speakers/authors intend to discuss either non-FDA approved or investigational use of products/devices.

Copyright Statement

Created and published by Vindico Medical Education, 6900 Grove Road, Building 100, Thorofare, NJ 08086-9447. Telephone: 856-994-9400; Fax: 856-384-6680. Printed in the USA. Copyright © 2019 Vindico Medical Education. All rights reserved. No part of this publication may be reproduced without written permission from the publisher. The material presented at or in any of Vindico Medical Education continuing medical education activities does not necessarily reflect the views and opinions of Vindico Medical Education. Neither Vindico Medical Education nor the faculty endorse or recommend any techniques, commercial products, or manufacturers. The faculty/authors may discuss the use of materials and/or products that have not yet been approved by the US Food and Drug Administration. All readers and continuing education participants should verify all information before treating patients or utilizing any product.

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