Mitigating Lack of Response to Antidepressant Therapy in Major Depressive Disorder: A Game On! Challenge

0.50 CME
$0 FEE


Provider Statement

This continuing medical education activity is provided by Vindico Medical Education.

Support Statement

This activity is supported by an educational grant from Takeda Pharmaceuticals U.S.A., Inc. and Lundbeck.

Activity Description

Depression is the most common psychiatric disorder and a leading cause of disability worldwide. The most recent data from the National Institute of Mental Health indicate that major depressive disorder (MDD) affects approximately 17 million American adults (or about 7% of the adult population) in any given year. The socioeconomic impact of MDD is substantial, as more than 50% of adults with the disorder experience some degree of difficulty with work, home, or social activities because of their symptoms. Internists often identify, diagnose, and initiate treatment for mental health conditions. In particular, most patients with depression seek help from their primary care physicians, and these physicians can provide continuity of care, while fostering long-term relationships with patients. In this CME activity, participants will play Game On!, a quiz of knowledge and confidence, in which they will answer questions on optimal ways to diagnose and treat MDD, especially on how to manage patients who are not responding to first-line therapy. 

Target Audience

The intended audience for this activity is internists, nurses, nurse practitioners, physician assistants and other health care professionals involved in the management of patients with major depressive disorder (MDD).

Learning Objective(s)

Upon successful completion of this activity, participants should be better able to:

  • Monitor patients with MDD to identify when there is an inadequate response to antidepressant therapy.
  • Determine when antidepressant therapy should be switched in patients who are experiencing an inadequate treatment response.
  • Incorporate the use of shared decision-making in patients with MDD, so that they are involved in treatment-related decisions.
  • Incorporate alternative treatment strategies when patients have an inadequate response to initial antidepressant therapy.
  • Recognize the importance of psychotherapeutic approaches in the overall management of patients with MDD.


Michael E. Thase, MD
Professor of Psychiatry
Perelman School of Medicine
University of Pennsylvania
Philadelphia, PA


Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP
Ronald A. Codario, Jr., MD

MIPS Qualifying Activity

Completion of this accredited CME activity meets the expectations of an Accredited Safety or Quality Improvement Program (IA_PSPA_28) for the Merit-based Incentive Payment Program (MIPS). Participants who successfully complete the activity and its performance assessment will receive printable documentation of successful completion for MIPS self-reporting.
To meet the criteria for improvement activities in the Merit-Based Incentive Payment System (MIPS) of QPP, accredited CME providers need to implement activities that:

  • address a quality or safety gap that is supported by a needs assessment or problem analysis, or support the completion of such a needs assessment as part of the activity;
  • have specific, measurable aim(s) for improvement;
  • include interventions intended to result in improvement;
  • include data collection and analysis of performance data to assess the impact of the interventions; and
  • define meaningful clinician participation in their activity, describe the mechanism for identifying clinicians who meet the requirements, and provide participant completion information.


Vindico Medical Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation

Vindico Medical Education designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.  

ABIM MOCSuccessful completion of this CME activity enables the participant to earn up to 0.50 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants who opt-in will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC points.

This enduring material is approved for 1 year from the date of original release, July 31, 2020 to July 30, 2021.

How to Participate in This Activity and Obtain CME Credit

To participate in this CME activity, you must read the objectives, answer the pretest questions, view the content, and complete the CME posttest and evaluation. Provide only one (1) correct answer for each question. A satisfactory score is defined as answering 80% of the posttest questions correctly. Upon receipt of the completed materials, if a satisfactory score on the posttest is achieved, Vindico Medical Education will issue an AMA PRA Category 1 Credit(s)™ Certificate.


In accordance with the Accreditation Council for Continuing Medical Education’s Standards for Commercial Support, all accredited providers are required to mitigate and disclose to the activity audience the relevant financial relationships of the planners, teachers, and authors involved in the development of accredited content. An individual has a relevant financial relationship if he or she has a financial relationship in any amount occurring in the last 12 months with a commercial interest whose products or services are discussed in the accredited activity content over which the individual has control. Relationship information appears below.

Faculty reports the following relationship(s)

Michael E. Thase, MD
Salary: (Spouse): Peleton Advantage
Royalty: American Psychiatric Foundation, Guilford Publications, Herald House, W.W. Norton & Company
Consulting Fee: Acadia, Akili, Alkermes PLC, Allergan, H. Lundbeck A/S, Jazz Pharmaceuticals, Johnson & Johnson

Reviewers report the following relationship(s)

Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP
No relevant financial relationships to disclose. 

Ronald A. Codario, Jr., MD
No relevant financial relationships to disclose.

Vindico Medical Education staff report the following relationship(s)

No relevant financial relationships to disclose.

Signed disclosures are on file at Vindico Medical Education, Office of Medical Affairs and Compliance.

Unlabeled and Investigational Usage

The audience is advised that this continuing medical education activity may contain references to unlabeled uses of US Food and Drug Administration (FDA)-approved products or to products not approved by the FDA for use in the United States. The faculty members have been made aware of their obligation to disclose such usage. All activity participants will be informed if any speakers/authors intend to discuss either non–FDA-approved or investigational use of products/devices.

Copyright Statement

Created and published by Vindico Medical Education, 6900 Grove Road, Building 100, Thorofare, NJ 08086-9447. Telephone: 856-994-9400; Fax: 856-384-6680. Printed in the USA. Copyright © 2020 Vindico Medical Education. All rights reserved. No part of this publication may be reproduced without written permission from the publisher. The material presented at or in any of Vindico Medical Education continuing medical education activities does not necessarily reflect the views and opinions of Vindico Medical Education. Neither Vindico Medical Education nor the faculty endorse or recommend any techniques, commercial products, or manufacturers. The faculty/authors may discuss the use of materials and/or products that have not yet been approved by the US Food and Drug Administration. All readers and continuing education participants should verify all information before treating patients or utilizing any product.

CME Questions?

Contact us at