Geriatric Psychopharmacology: July 2015
Keck School of Medicine of USC and Psychiatric Annals
Table of Contents
Geriatric Psychopharmacology: Pharmacokinetic and Pharmacodynamic Considerations
Andrew D. Carlo, MD; and Jonathan E. Alpert, MD, PhD
The Use of Hypnotics to Treat Sleep Problems in the Elderly
Catherine McCall, MD; and John W. Winkelman, MD, PhD
Antipsychotics for Neuropsychiatric Symptoms of Dementia—Safety and Efficacy in the Context of Informed Consent
Kasia Gustaw Rothenberg, MD, PhD; and Ilse R. Wiechers, MD, MPP, MHS
Psychopharmacologic Agents to Enhance Cognition in Alzheimer’s Disease
Alireza Atri, MD, PhD; and Theodore A. Stern, MD
Sponsorship Statement: This CME activity is jointly sponsored by Keck School of Medicine of USC and Psychiatric Annals.
Support Statement: There is no commercial support for this activity.
1. Identify the pharmacokinetic and pharmacodynamic factors relevant to prescribing medication in older adults.
2. Identify and manage sleep problems in the elderly.
3. Describe the risks, benefits, and alternatives for the use of antipsychotics for the treatment of neuropsychiatric symptoms of dementia.
4. Identify pharmacologic management strategies to promote cognitive enhancement in Alzheimer’s disease.
Faculty names and affiliations: See authors above
Guest Editor:Theodore A. Stern, MD
Reviewer names: Jan Fawcett, MD, Editor, Psychiatric Annals; Andrew A. Nierenberg, MD, CME Coordinator, Psychiatric Annals
Disclosure statement: In accordance with the Accreditation Council for Continuing Medical Education’s Standards for Commercial Support, all CME providers are required to disclose to the activity audience the relevant financial relationships of the planners, teachers, and authors involved in the development of CME content. An individual has a relevant financial relationship if he or she has a financial relationship in any amount occurring in the last 12 months with a commercial interest whose products or services are discussed in the CME activity content over which the individual has control. Relationship information appears at the beginning of each CME-accredited article in this issue and also on this page.
Faculty members report the following financial relationships:
Jan Fawcett, MD, has no relevant financial relationships to disclose.
Andrew A. Nierenberg, MD, has disclosed the following relevant financial relationships: Appliance Computing Inc. (Mindsite); Astra Zeneca; Brain Cells, Inc.; Brandeis University; Bristol Myers Squibb; Clintara, Dianippon Sumitomo/Sepracor; Eli Lilly and Company; EpiQ, Forest; Johnson and Johnson; Labopharm; Merck; Methylation Science; Novartis; PamLabs; PGx Health; Shire; Schering-Plough; Sunovion; Takeda/Lundbeck Pharmaceuticals; Targacept; Teva: Consultant. APSARD; Belvoir Publishing; Boston Center for the Arts; University of Texas Southwestern Dallas; Hillside Hospital; American Drug Utilization Review; American Society for Clinical Psychopharmacology; Bayamon Region Psychiatric Society; Baystate Medical Center; Canadian Psychiatric Association; Columbia University; Douglas Hospital/McGill University; IMEDEX; International Society for Bipolar Disorders; Israel Society for Biological Psychiatry; John Hopkins University; MJ Consulting; Massachusetts Association of College Counselors; Medscape; MBL Publishing; Physicians Postgraduate Press; Ryan Licht Sang Foundation; Slack Publishing; SUNY Buffalo; University of Florida; University of Miami; University of Wisconsin; University of Pisa; SciMed: Honoraria / travel expenses. Appliance Computing, Inc.; Brain Cells, Inc.: Stock options. AHRQ; Cephalon; Forest; Mylan; NIMH; PamLabs; Pfizer Pharmaceuticals; Takeda; Elan; Shire: Grant / research support.
Authors report the following financial relationships: Andrew D. Carlo has no relevant financial relationships to disclose. Jonathan E. Alpert has no relevant financial relationships to disclose. Catherine McCall has no relevant financial relationships to disclose. John W. Winkelman has received consulting fees from UCB Pharma, Xenopart, INSYS Therapeutics, Merck & Co., and Flex Pharma; has performed contracted research for Purdue, Xenopart, UCB Pharma, and Neurometrix; and has provided expert testimony for Canter Colburn. Kasia Gustaw Rothenberg has no relevant financial relationships to disclose. Ilse R. Wiechers, has has no relevant financial relationships to disclose. Alireza Atri discloses royalties received from Oxford University Press; consulting fees received from Actavis/Forest Laboratories, Merck & Co., and Lundbeck; and an institutional research contract from Lundbeck. Theodore A. Stern discloses a salary received from the Academy of Psychosomatic Medicine and royalties received from Elsevier and Massachusetts General Hospital.
The staff of Keck School of Medicine of USC and Psychiatric Annals have disclosed no relevant financial relationships.
Signed disclosures are on file at Keck School of Medicine of USC.
Accreditation statement(s): This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Keck School of Medicine of USC and SLACK Incorporated. The Keck School of Medicine of USC is accredited by the ACCME to provide continuing medical education for physicians.
Credit designation: The Keck School of Medicine of USC designates this enduring material for a maximum of 3 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Release date: July 1, 2015.
Expiration Date: July 31, 2018.
How to participate: To participate in this CME activity, you must read the learning objectives, answer the pretest questions, read the articles, complete the CME posttest, and complete the evaluation. Provide only one (1) correct answer for each question. A satisfactory score is defined as answering 70% of the posttest questions correctly. Upon receipt of the completed materials, if a satisfactory score on the posttest is achieved, Keck School of Medicine of USC will issue an AMA PRA Category 1 Credit(s)™ certificate.
Target audience: This CME activity is primarily targeted to patient-caring psychiatrists, physicians specializing in psychiatry and others allied to the field. There are no specific background requirements for participants taking this activity. Learning objectives and author disclosures are found at the beginning of each CME article.
Unlabeled and investigational usage statement: The audience is advised that this continuing medical education activity may contain references to unlabeled uses of FDA-approved products or to products not approved by the FDA for use in the United States. The faculty members have been made aware of their obligation to disclose such usage.
Copyright statement: Copyright © 2015 by SLACK Incorporated. All rights reserved. No part of this publication may be reproduced without prior written consent of the publisher.