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Rheumatoid Arthritis: Mechanisms of Autoimmunity, Immunogenicity, and Advances in Immunotherapy

Author(s)/Faculty: Leonard H. Calabrese, DO; Jonathan Kay, MD; Gregg J. Silverman, MD
Release Date: 9/15/2015Expiration Date: 8/15/2018
Credit Type: CMENumber of Credits: 0
Content Type: ArticleProvider:
Rheumatoid arthritis (RA) is an autoimmune disease characterized by a dysregulation of inflammatory processes leading to progressive joint destruction, systemic inflammation, and extra-articular manifestations. By understanding the underlying immunologic mechanisms driving RA progression, clinicians involved in the management of patients with RA will be better equipped to evaluate the clinical and pharmacologic safety, as well as efficacy profiles of current and emerging disease modifying antirheumatic drugs (DMARDs). This monograph integrates a discussion between the basic and clinical immunologic sciences to give learners a better understanding of autoimmunity, treatment-associated immunogenicity, and the development of biosimilars for RA management.