IBECARTICLECME

Best of Immunology and Biologics Educational Collaborative (IBEC) 2016: Focus on Advancements in Rheumatoid and Inflammatory Arthritis

Author(s)/Faculty: Leonard H. Calabrese, DO; Jonathan Kay, MD; William F.C. Rigby, MD
Release Date: 12/15/2016Expiration Date: 12/15/2017
Credit Type: CMENumber of Credits: 1.25
Content Type: ArticleProvider: Vindico Medical Education
Rheumatoid arthritis (RA) is a progressive and painful systemic inflammatory disease that preferentially attacks the synovium of the joint, leading to joint destruction, debility, and deformity. Increased understanding of the underlying pathophysiology of RA has made a remarkable difference in its treatment and prognosis. Numerous therapeutic agents with diverse targets and mechanisms have been added to the RA armamentarium, allowing for intervention at various stages in the pathogenic process of the disease. Mechanisms of autoimmunity and inflammation will be compared to the emerging role of checkpoint therapy and small molecules in novel treatment approaches. By understanding the underlying immunologic mechanisms driving RA progression, clinicians involved in the management of patients with RA will be better equipped to evaluate the clinical and pharmacologic safety, as well as efficacy profiles of current and emerging therapies. This monograph will review checkpoint and small molecule therapy for RA, as well as early RA and use of biosimilars in clinical practice.